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Ibuprofen and Tramadol
Tramadol hydrochloride (Ultram®) is a prescription opioid pain reliever. Ibuprofen (Advil®, Motrin®, Nuprin®) is a nonsteroidal anti-inflammatory drug (NSAID) that is available both over-the-counter and with a prescription, depending on the strength. There is no significant drug interaction between tramadol and ibuprofen.
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